InterPro domain: IPR017390

General Information

  • Identifier IPR017390
  • Description Ubiquitinyl hydrolase, UCH37 type
  • Number of genes 135
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004843   GO:0016579  

Abstract

This group represents an ubiquitin carboxyl-terminal hydrolase, UCH37 (also known as UCHL5) type.

Human UCH37 is a protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. It is also a deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome [ 1 , 2 ].

This entry also includes fission yeast Uch2, which is an ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins [ 3 ].


1. Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat. Cell Biol. 8, 994-1002
2. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Mol. Cell 31, 909-17
3. Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast. J. Mol. Biol. 344, 697-706

Species distribution

Gene table