InterPro domain: IPR017389

General Information

  • Identifier IPR017389
  • Description Nucleoporin, NUP53

Abstract

The nuclear pore complex (NPC) mediates the transport of macromolecules acrossthe nuclear envelope (NE). The NPC is composed of a relatively small number ofproteins (~30), termed nucleoporins or Nups. The vertebrate nuclear poreprotein Nup35, the orthologue of Saccharomyces cerevisiae Nup53p, is suggested to interact with the NE membrane and to be required for nuclear morphology [ 1 ].

This entry also includes Asm4 (a paralogue of Saccharomyces cerevisiae Nup53p) from Saccharomyces cerevisiae and Nup40 from Schizosaccharomyces pombe.


1. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. Mol. Biol. Cell 16, 2382-94

Species distribution

Gene table