InterPro domain: IPR017380

General Information

  • Identifier IPR017380
  • Description Histone acetyltransferase type B, catalytic subunit

Abstract

This entry represents the catalytic subunit of histone acetyltransferase type B ( 2.3.1.48 ) (also known as HAT1), which is the catalytic component of the histone acetylase B (HAT-B) complex [ 1 , 2 , 3 ]. The HAT-B complex is composed of at least HAT1 and HAT2. In the cytoplasm, this complex binds to the histone H4 tail. In the nucleus, the HAT-B complex has an additional component, the histone H3/H4 chaperone HIF1.

This enzyme acetylates soluble but not nucleosomal H4 at Lys-12, which is required for telomeric silencing. HAT1 has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. It is involved in DNA double-strand break repair [ 4 ].


1. Histone acetyltransferase-1 regulates integrity of cytosolic histone H3-H4 containing complex. Biochem. Biophys. Res. Commun. 373, 624-30
2. Site specificity of yeast histone acetyltransferase B complex in vivo. FEBS J. 275, 2122-36
3. Hat1: the emerging cellular roles of a type B histone acetyltransferase. Oncogene 26, 5319-28
4. Histone H3 and the histone acetyltransferase Hat1p contribute to DNA double-strand break repair. Mol. Cell. Biol. 22, 8353-65

Species distribution

Gene table