InterPro domain: IPR017340

General Information

  • Identifier IPR017340
  • Description U1 small nuclear ribonucleoprotein C

Abstract

This group represents U1 small nuclear ribonucleoprotein C. It is a component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA [ 1 , 2 , 3 ].


1. U1-specific protein C needed for efficient complex formation of U1 snRNP with a 5' splice site. Science 247, 69-72
2. Zinc finger-like structure in U1-specific protein C is essential for specific binding to U1 snRNP. Nucleic Acids Res. 19, 449-54
3. Involvement of U1 small nuclear ribonucleoproteins (snRNP) in 5' splice site-U1 snRNP interaction. J. Biol. Chem. 271, 23985-91

Species distribution

Gene table

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