InterPro domain: IPR017340
General Information
- Identifier IPR017340
- Description U1 small nuclear ribonucleoprotein C
- Number of genes 177
- Gene duplication stats Loading...
- Associated GO terms GO:0005685 GO:0000387 GO:0000398
Abstract
This group represents U1 small nuclear ribonucleoprotein C. It is a component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA [ 1 , 2 , 3 ].
1. U1-specific protein C needed for efficient complex formation of U1 snRNP with a 5' splice site. Science 247, 69-72
2. Zinc finger-like structure in U1-specific protein C is essential for specific binding to U1 snRNP. Nucleic Acids Res. 19, 449-54
3. Involvement of U1 small nuclear ribonucleoproteins (snRNP) in 5' splice site-U1 snRNP interaction. J. Biol. Chem. 271, 23985-91