InterPro domain: IPR017074

General Information

  • Identifier IPR017074
  • Description mRNA capping enzyme, bifunctional

Abstract

This entry represents bifunctional mRNA-capping enzymes that exhibit RNA 5'-triphosphatase activity ( 3.1.3.33 ) in the N-terminal region and mRNA guanylyltransferase activity ( 2.7.7.50 ) in the C-terminal region. These enzymes catalyse the first two steps of cap formation via the following steps:

  • Removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end.
  • Followed by the transfer of the gmp moiety of GTP to the 5'-diphosphate terminus.

Species distribution

Gene table