InterPro domain: IPR016903

Budding yeast nucleolar complex-associated protein 3 (Noc3) is required for initiation of DNA replication and for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm [ 1 , 2 ]. This entry also includes Noc3 homologues from animals and plants. The mammalian Noc3 is a positive regulator in adipocyte differentiation [ 3 ].

1. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Cell 105, 499-509
2. Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Cell 109, 849-60
3. Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. J. Cell. Sci. 117, 6217-26