InterPro domain: IPR016902
General Information
- Identifier IPR016902
- Description Vacuolar protein sorting-associated protein 41
- Number of genes 124
- Gene duplication stats Loading...
- Associated GO terms GO:0046907
Abstract
This entry represents a vacuolar protein sorting-associated protein Vps41 which is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport [ 1 , 2 , 3 ].
1. A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc. Natl. Acad. Sci. U.S.A. 97, 9402-7
2. Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component. EMBO J. 16, 2769-82
3. Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 272, 11344-9