InterPro domain: IPR016899

mRNA (guanine-N(7))-methyltransferase methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. It binds RNA containing 5'-terminal GpppC [ 1 , 2 , 3 , 4 , 5 , 6 ]. This family of enzymes is found in nucleus [ 7 , 8 , 9 ].

1. Cloning and characterization of mRNA capping enzyme and mRNA (Guanine-7-)-methyltransferase cDNAs from Xenopus laevis. Biochem. Biophys. Res. Commun. 268, 617-24
2. Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene. Mol. Cell. Biol. 15, 4167-74
3. Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase. Biochem. Biophys. Res. Commun. 251, 27-34
4. Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. J. Biol. Chem. 273, 21443-6
5. Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes. J. Biol. Chem. 274, 16553-62
6. RAM/Fam103a1 is required for mRNA cap methylation. Mol. Cell 44, 585-96
7. Dynamic association of capping enzymes with transcribing RNA polymerase II. Genes Dev. 14, 2435-40
8. Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-alpha. Genes Dev. 14, 2944-9
9. Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability. Mol. Cell. Biol. 25, 2644-9