InterPro domain: IPR016721

This entry includes Bet3 (also known as TRAPPC3) and Bet3-like (TRAPPC3L) proteins from eukaryotes. They seem to be involved in vesicle-mediated transport

.

Yeast Bet3 is a core component of transport protein particle (TRAPP) complexes I-III. The TRAPPI complex recognises the coat (COPII) on ER-derived vesicles, whereas the TRAPPII complex recognises the coat (COPI) on Golgi-derived vesicles [ 1 ]. TRAPPIII is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy [ 2 ].

Mammalian TRAPPs complexity is increased by the presence of multiple TRAPP homologues and novel subunits or binding proteins that are not part of the yeastTRAPP complexes [ 3 ]. Bet3 and its homologue Bet3-like are both components of the mammalian TRAPP complex [ 4 ].

1. Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc. Natl. Acad. Sci. U.S.A. 107, 7811-6
2. TRAPPIII is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy. J. Cell. Sci. 126, 4963-73
3. A trapper keeper for TRAPP, its structures and functions. Cell. Mol. Life Sci. 69, 3933-44
4. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. Mol. Biol. Cell 22, 2083-93