InterPro domain: IPR016692

General Information

  • Identifier IPR016692
  • Description Sulfiredoxin
  • Number of genes 105
  • Gene duplication stats Loading...
  • Associated GO terms GO:0032542  

Abstract

Sulfiredoxins 1.8.98.2 belong to the oxidoreductase family, which are involved in cellular responses to oxidative stress [ 1 ]. They catalyse the reaction peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R

It is a member of a conserved family of eukaryotic antioxidants and contains a conserved C-terminal cysteine which is essential for its antioxidant function.

Sulfiredoxin (Srx) plays a role in signalling through the catalytic reduction of oxidative modifications. It is responsible for the regulation of peroxiredoxin (Prx) by catalysing reduction of the conserved cysteine from sulfinic to sulfenic acid. This reduction prevents further reduction to sulfonic acid, which ultimately results in degradation.

Srx also has a role in glutathionylation.


1. Sulfiredoxin: a potential therapeutic agent? Biomed. Pharmacother. 59, 374-9

Species distribution

Gene table