InterPro domain: IPR016689

General Information

  • Identifier IPR016689
  • Description ESCRT-2 complex, Snf8
  • Number of genes 131
  • Gene duplication stats Loading...
  • Associated GO terms GO:0000814   GO:0071985  

Abstract

Snf8 (also known as Vps22p/Eap30) is a subunit of ESCRT-II, a protein complex involved in driving protein sorting from endosomes to lysosomes.

The multivesicular body (MVB) protein-sorting pathway targets transmembraneproteins either for degradation or for function in the vacuole/lysosomes. Thesignal for entry into this pathway is monoubiquitination of protein cargo,which results in incorporation of cargo into luminal vesicles at lateendosomes. Another crucial player is phosphatidylinositol 3-phosphate(PtdINS(3)P), which is enriched on early endosomes and on the luminal vesiclesof MVBs. ESCRT (endosomal sorting complex required for transport)-I, -II and -III complexes are critical for MVB budding and sorting ofmonoubiquitinated cargo into the luminal vesicles [ 1 ].


1. The emerging shape of the ESCRT machinery. Nat. Rev. Mol. Cell Biol. 8, 355-68

Species distribution

Gene table

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