InterPro domain: IPR016661

General Information

  • Identifier IPR016661
  • Description Prefoldin, subunit 4
  • Number of genes 126
  • Gene duplication stats Loading...
  • Associated GO terms GO:0016272   GO:0006457  

Abstract

This group represents a prefoldin, subunit 4 (PFDN4, also known as Gim3 in budding yeasts). PFDN4 is part of the prefoldin heterohexamer copmlex (consists of two PFD-alpha type and four PFD-beta type subunits) that binds specifically to cytosolic chaperonin (c-CPN) and transfers targeted proteins to it. It binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins [ 1 , 2 ].


1. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell 93, 863-73
2. S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Mol. Cell 28, 28-40

Species distribution

Gene table