InterPro domain: IPR016653

Yeast tRNA (guanine(9)-N1)-methyltransferase TRM10 catalyses the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNAs [ 1 , 2 ]. This group also includes metazoa homologue A (TRM10A). In humans there are three TRM10 orthologues; a nonsense mutation in TRMT10A has been associated with microcephaly [ 3 ].

1. Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9. RNA 9, 574-85
2. Detection and discovery of RNA modifications using microarrays. Nucleic Acids Res. 33, e2
3. TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly. J. Med. Genet. 51, 581-6