InterPro domain: IPR016650

General Information

  • Identifier IPR016650
  • Description Eukaryotic translation initiation factor 3 subunit E

Abstract

Eukaryotic translation initiation factor 3 subunit E (eIF3e) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome [ 1 , 2 ]. In humans, eIF3e is required for nonsense-mediated mRNA decay [ 3 ].


1. Conservation and diversity of eukaryotic translation initiation factor eIF3. J. Biol. Chem. 272, 1101-9
2. PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes. BMC Biol. 3, 14
3. Human INT6/eIF3e is required for nonsense-mediated mRNA decay. EMBO Rep. 8, 596-602

Species distribution

Gene table