InterPro domain: IPR016635
General Information
- Identifier IPR016635
- Description Adaptor protein complex, sigma subunit
- Number of genes 694
- Gene duplication stats Loading...
- Associated GO terms GO:0015031
Abstract
The adaptor protein complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules [ 1 ]. Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Subunits of clathrin-associated adaptor protein complex 1 play a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or in endosomes.
This group represents an adaptor protein complex, sigma subunit.
1. The clathrin adaptor complexes as a paradigm for membrane-associated allostery. Protein Sci 22, 517-29