InterPro domain: IPR016574

General Information

  • Number of genes 151
  • Gene duplication stats Loading...
  • Associated GO terms GO:0016020   GO:0009966  

Abstract

Nicalin is a Nodal signalling antagonist and a distant homologue of the gamma-secretase component Nicastrin [ 1 ]. In humans, Nicalin forms a complex with NOMO (Nodal modulator) and controls the assembly and stability of this complex [ 2 ].


1. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. EMBO J. 23, 3041-50
2. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. J. Biol. Chem. 282, 10632-8

Species distribution

Gene table