InterPro domain: IPR016555

This entry includes the lipid-signaling enzymes phospholipase D1 (PLD1) and D2 (PLD2) [ 1 ]. They have roles in immune cell migration [ 2 , 3 ] and phagocytosis [ 4 , 5 ]. PLD1 is selectively required during extravasation of macrophages from the bloodstream to sites of damage [ 6 ].

1. Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr. Biol. 7, 191-201
2. The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts. Mol. Cell. Biol. 30, 4492-506
3. Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science 324, 384-7
4. Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis. J. Immunol. 173, 2615-23
5. Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis. Traffic 7, 365-77
6. Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment. PLoS ONE 8, e55325