InterPro domain: IPR016528
General Information
- Identifier IPR016528
- Description Vacuolar protein sorting-associated protein 11
- Number of genes 133
- Gene duplication stats Loading...
Abstract
This entry includes E3 ubiquitin-protein ligase Pep5 (also known as vacuolar protein sorting-associated protein 11, Vps11) from fungi, and its homologues from plants and animals. Pep5 is a peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis [ 1 ]. It is also identified as an E3 ubiquitin ligase that regulates histone protein levels in Saccharomyces cerevisiae [ 2 ]. Human Vps11 may play a role in vesicle-mediated protein trafficking [ 3 ].
1. Pep3p/Pep5p complex: a putative docking factor at multiple steps of vesicular transport to the vacuole of Saccharomyces cerevisiae. Genetics 156, 105-22
2. Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae. PLoS ONE 7, e36295
3. Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. J. Biol. Chem. 276, 29393-402