InterPro domain: IPR016435

General Information

  • Identifier IPR016435
  • Description Diphthamide synthesis DPH1/DPH2
  • Number of genes 256
  • Gene duplication stats Loading...

Abstract

Archaeal and eukaryotic translation elongation factor 2 contain a unique posttranslationally modified histidine residue called diphthamide, the target of the diphtheria toxin. Diphtheria toxin inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide in EF2 [ 1 ].

Members of this family include DPH1 and DPH2, which are involved in the first step of diphthamide synthesis [ 2 ]. Archaeal DPHs are more similar to eukaryotic DPH1 than to DPH2 [ 2 ].


1. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. Mol. Cell. Biol. 24, 9487-97
2. Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Nature 465, 891-6

Species distribution

Gene table