InterPro domain: IPR016346
General Information
- Identifier IPR016346
- Description Guanine nucleotide-binding protein, beta subunit
- Number of genes 170
- Gene duplication stats Loading...
- Associated GO terms GO:0007165
Abstract
G protein is a modulator in various transmembrane signalling systems. The beta and gamma subunits are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This entry represents the G protein (guanine nucleotide-binding proteins) beta subunit, including Ste4 from budding yeasts [ 1 ], Git5 from fission yeasts [ 2 ] and GNB1-5 from animals [ 3 ].
1. The STE4 and STE18 genes of yeast encode potential beta and gamma subunits of the mating factor receptor-coupled G protein. Cell 56, 467-77
2. Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits. Fungal Genet. Biol. 43, 840-51
3. Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families. Mol. Phylogenet. Evol.