InterPro domain: IPR016301
General Information
- Identifier IPR016301
- Description Phosphoribosylaminoimidazole carboxylase, fungi/plant
- Number of genes 103
- Gene duplication stats Loading...
- Associated GO terms GO:0004638 GO:0006189
Abstract
The novo purine biosynthesis proceeds by two divergent paths. In bacteria, yeasts, and plants, 5-aminoimidazole ribonucleotide (AIR) is converted to 4-carboxy-AIR (CAIR) by two enzymes: N5-carboxy-AIR (N5-CAIR) synthetase (PurK) and N5-CAIR mutase (class I PurE). In animals, the conversion of AIR to CAIR requires a single enzyme, AIR carboxylase (class II PurE) [ 1 ].
This entry represents the fungi and plant fusion protein known as Ade2. It is a phosphoribosylaminoimidazole carboxylase consisting of two distinct domains, an N-terminal domain homologous to PurK (N5-CAIR synthetase), and a C-terminal domain homologous to PurE (N5-CAIR mutase) [ 2 ].
1. Treponema denticola PurE Is a bacterial AIR carboxylase. Biochemistry 50, 4623-37
2. Sequence analysis of the Candida albicans ADE2 gene and physical separation of the two functionally distinct domains of the phosphoribosylaminoimidazole carboxylase. Yeast 13, 769-76