InterPro domain: IPR016280

General Information

  • Identifier IPR016280
  • Description Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
  • Number of genes 1
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004435   GO:0005509  

Abstract

This group represents phospholipase C-beta, also known as 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta. PLC-beta isoforms mediate the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) to propagate signalsfor several physiological responses [ 1 , 2 ]. This entry also includes NorpA, a phospholipase C (PLC) from Drosophila expressed in the eye. NorpA is a essential component of the phototransduction pathway in Drosophila [ 3 ].


1. Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1). Biochim. Biophys. Acta 1517, 63-72
2. Membrane-induced allosteric control of phospholipase C-β isozymes. J. Biol. Chem. 289, 29545-57
3. Isolation of a putative phospholipase C gene of Drosophila, norpA, and its role in phototransduction. Cell 54, 723-33

Species distribution

Gene table