InterPro domain: IPR016278

Human YVH1, also known as dual specificity phosphatase 12 (DUSP12), is a cell survival phosphatase that prevents both thermal and oxidative stress-induced cell death. Furthermore, it associates with multiple ribonucleoprotein particles and may affect a variety of fundamental cellular processes [ 1 ]. The enzyme is known as dual specificity protein phosphatase MPK-4 in Drosophila [ 2 ]. Yeast YVH1, on the other hand, is required for a late maturation step in the 60S biogenesis pathway [ 3 ].

1. The Atypical Dual Specificity Phosphatase hYVH1 Associates with Multiple Ribonucleoprotein Particles. J. Biol. Chem. 292, 539-550
2. Molecular identification and functional characterization of a Drosophila dual-specificity phosphatase DMKP-4 which is involved in PGN-induced activation of the JNK pathway. Cell. Signal. 20, 1329-37
3. Yvh1 is required for a late maturation step in the 60S biogenesis pathway. J. Cell Biol. 186, 863-80