InterPro domain: IPR016267

General Information

  • Identifier IPR016267
  • Description UTP--glucose-1-phosphate uridylyltransferase
  • Number of genes 313
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006011   GO:0003983  

Abstract

UDP-glucose is the universal activated form of glucose, employed in all organisms for glucosyl transfer reactions and as precursor for various activated carbohydrates [ 1 ]. It is formed by the enzyme UDP-glucose pyrophosphorylase (UGPase, UDPGP), also known as UTP--glucose-1-phosphate uridylyltransferase, ( 2.7.7.9 ), which catalyses the reaction UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose. The enzymatically active form of the protein is a homooctamer in Saccharomyces cerevisiae [ 2 ].


1. Structural basis for subunit assembly in UDP-glucose pyrophosphorylase from Saccharomyces cerevisiae. J. Mol. Biol. 364, 551-60

Species distribution

Gene table