InterPro domain: IPR016177

This superfamily represents a DNA-binding domain with a 2-layer beta(3)-alpha fold that is found in several DNA-binding proteins, including:

• DNA-binding domain of tn916 integrase [ 1 ].
• N-terminal DNA-binding domain of lambda integrase [ 2 ].
• GCC-box DNA-binding domains of certain transcription factors [ 3 ].
• Methyl-CpG DNA-binding domain found in Methyl-CpG-binding protein 2 (MECP2) [ 4 ] and methylation-dependent transcriptional repressor MBD1/PCM1 [ 5 ].

1. Site-specific DNA binding using a variation of the double stranded RNA binding motif. Nat. Struct. Biol. 5, 546-50
2. A structural basis for allosteric control of DNA recombination by lambda integrase. Nature 435, 1059-66
3. A novel mode of DNA recognition by a beta-sheet revealed by the solution structure of the GCC-box binding domain in complex with DNA. EMBO J. 17, 5484-96
4. The solution structure of the domain from MeCP2 that binds to methylated DNA. J. Mol. Biol. 291, 1055-65
5. Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA. Cell 105, 487-97