InterPro domain: IPR016171

The C-terminal domain of certain FAD-linked oxidases consist of two structural subdomains: subdomain 1 is a 2-layer a/b or 3-layer a/b/a sandwich, and subdomain 2 is either an orthogonal alpha-bundle or a second 2-layer a/b sandwich. This superfamily represents the second (C-terminal) subdomain with an orthogonal alpha-bundle fold. This subdomain is found in members of the vanillyl-alcohol family, which includes the flavoprotein vanillyl-alcohol oxidase ( 1.1.3.38 ) [ 1 ] as well as the flavoprotein subunit of p-cresol methylhydroxylase ( 1.17.9.1 ) (the other subunit being a short chain cytochrome c) [ 2 ], both of these enzymes contain covalently bound FAD.

1. Covalent flavinylation is essential for efficient redox catalysis in vanillyl-alcohol oxidase. J. Biol. Chem. 274, 35514-20
2. p-Cresol methylhydroxylase: alteration of the structure of the flavoprotein subunit upon its binding to the cytochrome subunit. Biochemistry 44, 2963-73