InterPro domain: IPR016095

Ribosomal protein L1 is the largest protein from the large ribosomal subunit. The L1 protein contains two domains: 2-layer alpha/beta domain and a 3-layer alpha/beta domain (interrupts the first domain). This entry represents the 3-layer domain.

It has been shown that the 2-layer alpha/beta-sandwich domain is for RNA binding. The 3-layer alpha/beta domain is to stabilise the L1-rRNA complex [ 1 ]. The 3-layer domain of ribosomal protein TthL1 hinders binding of intactprotein with RNA due to interdomain flexibility. As a result, the rate of complex formation with mRNA increases for the isolated domain I as compared withthat for intact TthL1 [ 2 ].

1. Domain I of ribosomal protein L1 is sufficient for specific RNA binding. Nucleic Acids Res. 35, 7389-95
2. Domain II of Thermus thermophilus ribosomal protein L1 hinders recognition of its mRNA. J. Mol. Biol. 383, 301-5