InterPro domain: IPR016088

Chalcone isomerase ( 5.5.1.6 ; also known as chalcone-flavanone isomerase or fatty-acid-binding protein) is a plant enzyme responsible for the isomerisation of chalcone to naringenin, a key step in the biosynthesis of flavonoids. The Petunia hybrida (Petunia) genome contains two genes coding for very similar enzymes, ChiA and ChiB, but only the first seems to encode a functional chalcone isomerase. This entry represents a 3-layer beta/beta/alpha sandwich subdomain found in chalcone isomerases [ 1 ].

1. Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase. Nat. Struct. Biol. 7, 786-91