InterPro domain: IPR016068
General Information
- Identifier IPR016068
- Description Translin, N-terminal
- Number of genes 254
- Gene duplication stats Loading...
- Associated GO terms GO:0043565
Abstract
Translins are DNA-binding proteins that specifically recognise consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. They seem to recognise single-sranded DNA ends generated by staggered breaks occuring at recombination hot spots [ 1 ].
Translin folds into an alpha-alpha superhelix, consisting of two curved layers of alpha/alpha topology [ 2 , 3 ]. This structure can be divided into two alpha-bundle subdomains. This entry represents the N-terminal alpha bundle subdomain.
1. Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX. FEBS Lett. 401, 109-12
2. Crystal structure of TB-RBP, a novel RNA-binding and regulating protein. J. Mol. Biol. 319, 1049-57
3. Structure of human translin at 2.2 A resolution. Acta Crystallogr. D Biol. Crystallogr. 60, 674-9