InterPro domain: IPR016040

This entry represents NAD- and NADP-binding domains with a core Rossmann-type fold, which consists of 3-layers alpha/beta/alpha, where the six beta strands are parallel in the order 321456. Many different enzymes contain an NAD/NADP-binding domain, including:

• C-terminal domain of alcohol dehydrogenases [ 1 ]
• Tyrosine-dependent oxidoreductases (also known as short-chain dehydrogenases) [ 2 ]
• N-terminal domain of glyceraldehyde-3-phosphate dehydrogenase [ 3 ]
• NAD-binding domain of formate/glycerate dehydrogenases [ 4 ]
• N-terminal domain of sirohaem synthase [ 5 ]
• N-terminal domain of lactate dehydrogenase [ 6 ]
• N-terminal domain of 6-phosphogluconate dehydrogenase (the beta-sheet is extended to 8 strands) [ 7 ]
• C-terminal domain of amino acid dehydrogenases (an extra N-terminal helix displaces the C-terminal helix [ 8 ]
• NAD-binding domain of certain potassium channels [ 9 ]
• C-terminal domain of the transcriptional repressor Rex [ 10 ]
• Ornithine cyclodeaminase [ 11 ]
• CoA-binding N-terminal domain of the alpha chain of succinyl-CoA synthetase [ 12 ]

1. Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors. Biochemistry 43, 12555-62
2. Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. Biochemistry 36, 6294-304
3. Crystal structure of the glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. J. Mol. Biol. 291, 651-60
4. High resolution structures of holo and apo formate dehydrogenase. J. Mol. Biol. 236, 759-85
5. CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis. Nat. Struct. Biol. 10, 1064-73
6. Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. Proteins 43, 175-85
7. Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates. FEBS J. 274, 275-86
8. The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures. Structure 3, 1147-58
9. Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron 29, 593-601
10. X-ray structure of a Rex-family repressor/NADH complex insights into the mechanism of redox sensing. Structure 13, 43-54
11. Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family. Biochemistry 43, 13883-91
12. A detailed structural description of Escherichia coli succinyl-CoA synthetase. J. Mol. Biol. 285, 1633-53