InterPro domain: IPR016009
General Information
- Identifier IPR016009
- Description tRNA methyltransferase TRMD/TRM10-type domain
- Number of genes 128
- Gene duplication stats Loading...
Abstract
This domain is found in tRNA methyltransferases including tRNA (guanine-N(1)-)-methyltransferases (TRMD) and mitochondrial ribonuclease P protein 1. Proteins containing this domain also include tRNA (guanine(9)-N1)-methyltransferase (Trm10) from yeasts.
Escherichia coli K12 tRNA (guanine-N(1)-)-methyltransferase catalyses the conversion of a guanosine residue to N1-methylguanine in position 37, next to the anticodon, in tRNA [ 1 ]. Mitochondrial RNase P (mtRNase P) functions in mitochondrial tRNA maturation [ 2 ].
1. Purification and characterization of transfer RNA (guanine-1)methyltransferase from Escherichia coli. J. Biol. Chem. 258, 1343-51
2. RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. Cell 135, 462-74