InterPro domain: IPR016005

General Information

  • Identifier IPR016005
  • Description Phosphomevalonate kinase Erg8
  • Number of genes 123
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004631  

Abstract

This entry includes phosphomevalonate kinase Erg8 from fungi and plants. Budding yeast Erg8 is involved in step 2 of the subpathway that synthesizes isopentenyl diphosphate from (R)-mevalonate [ 1 , 2 ]. Arabidopsis Erg8 (AT1G31910, also known as PMK) is involved in the mevalonic acid pathway [ 3 ].


1. Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase. Mol. Cell. Biol. 11, 620-31
2. Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway. Mol. Gen. Genet. 154, 269-77
3. Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta. Planta 234, 903-14

Species distribution

Gene table