InterPro domain: IPR015895

General Information

  • Identifier IPR015895
  • Description Glutamyl-tRNA reductase, N-terminal

Abstract

This entry represents the N-terminal domain of glutamyl-tRNA reductase ( 1.2.1.70 ), which reduces glutamyl-tRNA to glutamate-1-semialdehyde during the first stage of tetrapyrrole biosynthesis by the C5 pathway [ 1 , 2 ]. The enzyme requires NADPH as a cofactor. This N-terminal domain is the catalytic domain [ 3 ].


1. Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum. Cell. Mol. Life Sci. 57, 1880-93
2. Glutamyl-transfer RNA: a precursor of heme and chlorophyll biosynthesis. Trends Biochem. Sci. 17, 215-8
3. Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein. null 111, 6630-5

Species distribution

Gene table