InterPro domain: IPR015844

Pantothenate kinase (PanK, 2.7.1.33 ) catalyses the conversion of CAATP and pantothenate to ADP and D-4'-phosphopantothenate, the key regulatory step in the biosynthesis of coenzyme A (CoA) [ 1 ]. Members in this entry represents a two-domain form with an additional C-terminal domain of unknown function. This type of pantothenate kinase is typical for eukaryotes. It is not related by sequence to bacterial PanK ( PIRSF000545 ) and differs in a number of biochemical properties (such as inhibition by acetyl-CoA) [ 2 , 2 ]. However, this group also includes proteins from several Gram-positive bacteria ( PIRSF036940 ) that are suggested to have originated from the eukaryotic form by lateral transfer [ 3 ].

Hallervorden-Spatz syndrome is caused by a defect in a pantothenate kinase gene [ 3 ].

For additional information please see [ 4 ].

1. Cloning and characterization of a eukaryotic pantothenate kinase gene (panK) from Aspergillus nidulans. J. Biol. Chem. 274, 2014-20
2. Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections. Antimicrob. Agents Chemother. 47, 2051-5
3. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. Nat. Genet. 28, 345-9
4. fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster. Genetics 157, 1267-76