InterPro domain: IPR015815

This entry contains related reductases/dehydrogenases:

• 3-hydroxyisobutyrate dehydrogenase (HIBADH) ( 1.1.1.31 ) catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate [ 1 ]. In eukaryotes, it is a homodimeric mitochondrial protein involved in valine catabolism. In Pseudomonas aeruginosa [ 2 ] (gene mmsB), it is involved in the distal valine metabolic pathway.
• 2-hydroxy-3-oxopropionate reductase ( 1.1.1.60 ) catalyses the NAP(P)H dependent reduction of 2-hydroxy-3-oxopropionate (tartronate semialdehyde) to D-glycerate.
• 2-(hydroxymethyl)glutarate dehydrogenase ( 1.1.1.291 ) catalyses the conversion of 2-formylglutarate to (S)-2-hydroxymethylglutarate [ 3 ].
• L-threonate dehydrogenase catalyses oxidation of L-threonate to 2-oxo-tetronate [ 4 ].
• Putative oxidoreductase GLYR1, also known as 3-hydroxyisobutyrate dehydrogenase-like protein or nuclear protein NP60, which regulates p38 MAP kinase activity [ 5 ].

1. Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate dehydrogenase. Evidence for its evolutionary relationship to other pyridine nucleotide-dependent dehydrogenases. J. Biol. Chem. 264, 5899-903
2. Characterization of the mmsAB operon of Pseudomonas aeruginosa PAO encoding methylmalonate-semialdehyde dehydrogenase and 3-hydroxyisobutyrate dehydrogenase. J. Biol. Chem. 267, 13585-92
3. Structural and kinetic properties of a beta-hydroxyacid dehydrogenase involved in nicotinate fermentation. J. Mol. Biol. 382, 802-11
4. Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars. Proc. Natl. Acad. Sci. U.S.A. 113, E4161-9
5. Nuclear protein NP60 regulates p38 MAPK activity. J. Cell. Sci. 119, 115-23