InterPro domain: IPR015791

General Information

  • Identifier IPR015791
  • Description Antimicrobial/protein inhibitor, gamma-crystallin-like
  • Number of genes 53
  • Gene duplication stats Loading...

Abstract

This structural domain is found in a family of proteins with a Greek key motif [ 1 ] that are related in structure to the beta/gamma crystallins. This group of proteins includes:

  • Streptomyces killer toxin-like protein SKLP
  • Antifungal protein, AFP1
  • Plant antimicrobial protein, MIAMP1
  • Streptomyces metalloproteinase inhibitor, SMPI [ 2 ].

Note: SMPI belongs to MEROPS inhibitor I36, clan IU. It inhibits members of the thermolysin family, MEROPS peptidase family M4, ( IPR001570 ) [ 3 ].


1. The Greek key motif: extraction, classification and analysis. Protein Eng. 6, 233-45
2. NMR structure of the Streptomyces metalloproteinase inhibitor, SMPI, isolated from Streptomyces nigrescens TK-23: another example of an ancestral beta gamma-crystallin precursor structure. J. Mol. Biol. 282, 421-33
3. Evolutionary families of peptidase inhibitors. Biochem. J. 378, 705-16

Species distribution

Gene table