InterPro domain: IPR015757
General Information
- Identifier IPR015757
- Description Calcineurin B protein
- Number of genes 8
- Gene duplication stats Loading...
- Associated GO terms GO:0005509 GO:0008597
Abstract
Calcineurin is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin and Nuclear factor of Activated T-cell (NFAT) proteins have been shown to participate in signalling cascades that govern the development and function of the immune, nervous, cardiovascular and musculoskeletal systems [ 1 ]. Calcineurin is a heterodimeric protein consisting of: i) a catalytic subunit calcineurin A, which contains an active site dinuclear metal centre, and ii) a tightly associated, myristoylated, Ca(2+)-binding subunit, calcineurin B [ 2 ].
1. Calcineurin: a central controller of signalling in eukaryotes. EMBO Rep. 5, 343-8
2. Calcineurin: form and function. Physiol. Rev. 80, 1483-521