InterPro domain: IPR015671

This domain is found in glioma tumour suppressor candidate region gene 1 (GLTSCR1) protein, and is typically between 105 and 124 amino acids in length. There is a single completely conserved residue F that may be functionally important. Mutations in the gene for this protein in humans leads to the development of oligodendrogliomas [ 1 ]. There is evidence that these protein interacts with SH3 domains [ 2 ].

1. Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas. Cancer 103, 2363-72
2. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Proteomics 7, 1775-85