InterPro domain: IPR015659

This entry includes a group of proline dehydrogenases (proline oxidases) found in bacteria, archaea and eukaryotes (mitochondria).

This entry includes FadM from Bacillus subtilis subsp. natto [ 1 ] and slgA from Drosophila melanogaster . They convert proline to delta-1-pyrroline-5-carboxylate [ 2 ]. This entry also includes mammalian hydroxyproline dehydrogenase which converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate [ 3 ].

1. Delta1-pyrroline-5-carboxylic acid formed by proline dehydrogenase from the Bacillus subtilis ssp. natto expressed in Escherichia coli as a precursor for 2-acetyl-1-pyrroline. J. Agric. Food Chem. 55, 5097-102
2. The sluggish-A gene of Drosophila melanogaster is expressed in the nervous system and encodes proline oxidase, a mitochondrial enzyme involved in glutamate biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 90, 2979-83
3. Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria. Biochem. J. 466, 273-81