InterPro domain: IPR015507

General Information

  • Identifier IPR015507
  • Description Ribosomal RNA large subunit methyltransferase E
  • Number of genes 85
  • Gene duplication stats Loading...
  • Associated GO terms GO:0001510   GO:0008168  

Abstract

The ribosomal RNA large subunit methyltransferase E ( 2.1.1 ) methylates the 23S rRNA. It specifically methylates the uridine in position 2552 of 23s rRNA in the 50S particle using S-adenosyl-L-methionine as a substrate [ 1 ]. It was previously known as cell division protein FtsJ.

This entry represents the ribosomal RNA large subunit methyltransferase E family, which also includes tRNA (uridine-2'-O-)-methyltransferases. This enzyme methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop [ 2 ].


1. The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase. J. Biol. Chem. 275, 16414-9
2. Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop. EMBO J. 21, 1811-20

Species distribution

Gene table