InterPro domain: IPR015418
General Information
- Identifier IPR015418
- Description Chromatin modification-related protein Eaf6
- Number of genes 181
- Gene duplication stats Loading...
- Associated GO terms GO:0016573 GO:0000123
Abstract
Eaf6 is a component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 histone acetyltransferase complex is conserved from yeast to humans [ 1 ]. Budding yeast Eaf6 is also a component of the NuA3 histone acetyltransferase complex that acetylates Lys-14 of histone H3 [ 2 ], while human Eaf6 is a component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity [ 3 ].
1. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol. Cell. Biol. 24, 1884-96
2. Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol. Cell 24, 785-96
3. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol. Cell. Biol. 28, 6828-43