InterPro domain: IPR015310

General Information

  • Identifier IPR015310
  • Description Activator of Hsp90 ATPase, N-terminal
  • Number of genes 284
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  • Associated GO terms GO:0051087   GO:0001671  

Abstract

This domain is predominantly found N-terminal in the protein Activator of Hsp90 ATPase (Aha1). Aha1 adopts a secondary structure consisting of an N-terminal alpha-helix leading into a four-stranded meandering antiparallel beta-sheet, followed by a C-terminal alpha-helix. The two alpha helices are packed together, with the beta-sheet curving around them. The N-terminal domain of Aha1 interacts with Hsp90 and stimulates its ATPase activity [ 1 ].


1. Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO J. 23, 1402-10

Species distribution

Gene table

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