InterPro domain: IPR015267

General Information

  • Identifier IPR015267
  • Description Protein phosphatase 4 core regulatory subunit R2
  • Number of genes 118
  • Gene duplication stats Loading...
  • Associated GO terms GO:0030289   GO:0019888  

Abstract

Protein phosphatase 4 core regulatory subunit R2 (PPP4R2), also known as Psy4 in budding yeast, is the regulatory subunit of the histone H2A phosphatase complex. The histone H2A phosphatase complex dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation of Psy4 is necessary for efficient recovery from the DNA damage checkpoint [ 1 ].


1. A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature 439, 497-501

Species distribution

Gene table