InterPro domain: IPR015257

Maf1 is a negative regulator of RNA polymerase III [ 1 , 2 ]. It inhibits the de novo assembly of TFIIIB onto DNA [ 3 ]. Maf1 represses Pol III in response to DNA damage, oxidative stress, growth to stationary phase, treatment with rapamycin or chlorpromazine, and blocking of the secretory pathway [ 4 ]. It targets the initiation factor TFIIIB [ 5 ]. Its structure has been solved [ 6 ].

1. Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae. Mol. Cell. Biol. 21, 5031-40
2. General repression of RNA polymerase III transcription is triggered by protein phosphatase type 2A-mediated dephosphorylation of Maf1. Mol. Cell 22, 623-32
3. Maf1 is involved in coupling carbon metabolism to RNA polymerase III transcription. Mol. Cell. Biol. 27, 7693-702
4. Signaling repression of transcription by RNA polymerase III in yeast. Prog. Nucleic Acid Res. Mol. Biol. 77, 323-53
5. Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription. Mol. Cell 10, 1489-94
6. Molecular basis of RNA polymerase III transcription repression by Maf1. Cell 143, 59-70