InterPro domain: IPR015222

General Information

  • Identifier IPR015222
  • Description Phosphatidate cytidylyltransferase, mitochondrial
  • Number of genes 137
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004605   GO:0032049  

Abstract

Tam41 is a mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase) that catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. It is required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane [ 1 , 2 ].


1. The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis. J. Cell Biol. 183, 1213-21
2. Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria. Cell Metab. 17, 709-18

Species distribution

Gene table