InterPro domain: IPR015168

This domain is found in NMT1/THI5 family proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine [ 1 , 2 , 3 ]. This domain is also found in aliphatic sulfonates-binding protein SsuA, which is part of a transport system for aliphatic sulfonates [ 4 ].

1. Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6. Yeast 19, 1261-76
2. nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine. J. Biol. Chem. 265, 10857-64
3. The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine. Microbiology (Reading, Engl.) 149, 1447-60
4. The Escherichia coli ssuEADCB gene cluster is required for the utilization of sulfur from aliphatic sulfonates and is regulated by the transcriptional activator Cbl. J. Biol. Chem. 274, 29358-65