InterPro domain: IPR015151

This entry represents a subdomain of the appendage (ear) domain of beta-adaptin. This domain has a three-layer arrangement, alpha-beta-alpha, with a bifurcated antiparallel beta-sheet [ 1 ]. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15) [ 2 ].

1. Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly. Proc. Natl. Acad. Sci. U.S.A. 96, 8907-12
2. The structure and function of the beta 2-adaptin appendage domain. EMBO J. 19, 4216-27