InterPro domain: IPR014929

General Information

  • Identifier IPR014929
  • Description E2 binding
  • Number of genes 130
  • Gene duplication stats Loading...
  • Associated GO terms GO:0019781   GO:0045116  

Abstract

E1 and E2 enzymes play a central role in ubiquitin and ubiquitin-like protein transfer cascades. This is an E2 binding domain that is found on NEDD8 activating E1 enzyme. The protein resembles ubiquitin, and recruits the catalytic core of the E2 enzyme Ubc12 in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains [ 1 ].


1. Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. Mol. Cell 17, 341-50

Species distribution

Gene table