InterPro domain: IPR014908

This entry represents the N-terminal domain of nucleoporin 133 (Nup133) and other nucleoporins, including Nup155, Nup15 and Nup170. It forms a seven-bladed beta propeller structure [ 1 ].

Nucleoporins are the main components of the nuclear pore complex (NPC) in eukaryotic cells, and mediate bidirectional nucleocytoplasmic transport, especially of mRNA and proteins. RNA undergoing nuclear export first encounters the basket of the nuclear pore and many nucleoporins are accessible on the basket side of the pore [ 2 , 3 ].

The S. Cerevisiae Nup-170, equivalent to the human Nup-155, contains two structural domains: an N-terminal beta-propeller and a C-terminal alpha-helical domain [ 4 ].

1. Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex. J. Cell Biol. 167, 591-7
2. Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA. Genomics 57, 144-51
3. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. J. Cell Biol. 155, 339-54
4. Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. J. Biol. Chem. 284, 28442-52