InterPro domain: IPR014893

General Information

  • Identifier IPR014893
  • Description Ku, C-terminal
  • Number of genes 123
  • Gene duplication stats Loading...

Abstract

The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Ku also binds RNA, mediating the assembly of DNA-PKcs which has a role in ribosomal RNA biogenesis [ 1 ]. This domain is found at the C-terminal of Ku which binds to DNA-PKcs [ 2 ].


1. DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis. Nature 579, 291-296
2. The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR). J. Mol. Biol. 335, 573-82

Species distribution

Gene table